CO2 Laser vs. Microneedling RF: Which Skin Treatment Is Right for You?

Not Getting Results from Botox Anymore? You’re Not Alone.
At Plump Medical Spa, we often hear from clients who say, “Botox used to work, but now it doesn’t.” This isn’t just your imagination—it could be a phenomenon known as Botox resistance.

Here’s what it is, why it happens, and what you can do about it.

⚠️ What Is Botox Resistance?

Botox resistance occurs when the body builds neutralizing antibodies against botulinum toxin type A, reducing or completely blocking its effect. It’s rare—but real.

Signs You Might Be Resistant:

  • Minimal or no muscle relaxation after treatment

  • Short-lived effects (less than 2 months)

  • Requires higher doses than before

🧪 Why Resistance Happens

  • Frequent dosing intervals (less than 12 weeks)

  • Large cumulative doses over time

  • Individual immune response

  • Product formulation differences

💉 How Plump Medical Spa Treats Botox Resistance

We offer a strategic approach to get your results back on track:

1. Switch to Myobloc or Xeomin

These neurotoxins use different formulations that may bypass existing antibody resistance.

  • Myobloc (Botulinum toxin type B): Great alternative for confirmed resistance

  • Xeomin: “Naked” toxin with no complexing proteins—less likely to cause resistance

2. Adjust Dosing & Timing

Spacing treatments appropriately can minimize immune buildup and enhance long-term outcomes.

3. Combination Therapy

We may pair neurotoxin with energy-based devices (e.g., microneedling RF or laser) for smoother skin without relying solely on injectables.

4. Advanced Assessment

Our team performs detailed evaluations to tailor your protocol based on your body’s unique response and aesthetic goals.

📍 Serving Orange County with Solutions that Work

We’ve helped clients from Irvine, Newport Beach, Santa Ana, and Costa Mesa regain confidence in their wrinkle-smoothing results. If Botox has stopped working for you, we’re here to guide you toward the next best step.