A 90-day physician-directed Tirzepatide microdosing protocol for patients who want the metabolic benefits of GLP-1 therapy without the side effect profile of full clinical dosing. Designed by Dr. Amir Mortazavi, MD at Plump Medical Spa in Newport Beach.
GLP-1 microdosing uses sub-therapeutic doses of Tirzepatide — doses below the standard weight-loss range — to deliver the metabolic and appetite-regulating benefits of GLP-1 therapy with a significantly reduced side effect profile.
It is not a weight-loss program in the traditional sense. It is a precision metabolic protocol — designed for patients who want GLP-1's effects on insulin sensitivity, appetite regulation, and metabolic function without the intensity of full clinical dosing.
Tirzepatide is a dual GLP-1/GIP receptor agonist — it acts on two pathways rather than one. Clinical evidence shows superior weight and metabolic outcomes compared to semaglutide, with improved tolerability for many patients. Dr. Mortazavi made this clinical decision based on the data and uses Tirzepatide for both full-dose and microdose protocols.
At sub-therapeutic doses, Tirzepatide produces a meaningful but gentler set of effects. Most microdose patients notice improvements in appetite regulation and energy within the first 2–3 weeks without the nausea or food aversion that can accompany standard dosing.
The microdosing protocol is a specific clinical tool — not a softer version of the weight loss program for everyone. Dr. Mortazavi assesses candidacy at consultation.
Every microdosing patient is evaluated and monitored personally by Dr. Mortazavi. This is not a telehealth prescription service. No online questionnaires. No automated refills. You see the physician at every stage of the protocol. Plump is one of the only practices in Newport Beach combining GLP-1 prescribing and aesthetic medicine — allowing patients to proactively address facial volume changes as part of the same care relationship.
What is GLP-1 microdosing?
GLP-1 microdosing uses sub-therapeutic doses of Tirzepatide — below the standard weight-loss range — to deliver metabolic and appetite-regulating benefits with a significantly reduced side effect profile. It is designed for patients seeking metabolic optimization rather than aggressive weight loss.
Does Plump use Semaglutide for microdosing?
No. Plump Medical Spa uses Tirzepatide exclusively — not Semaglutide. Dr. Mortazavi uses Tirzepatide for both full-dose and microdose protocols based on clinical evidence showing superior outcomes and tolerability with its dual GLP-1/GIP mechanism.
How is microdosing different from the full weight loss program?
The full weight loss program ($600–$800/month) uses standard therapeutic doses targeting 15–22% body weight loss. The microdosing program ($750 for 90 days) uses sub-therapeutic doses focused on metabolic optimization, weight maintenance, and gentler appetite regulation — not aggressive fat loss.
Who is a good candidate for the microdosing program?
Weight maintenance patients, metabolic optimization patients at a healthy weight, first-time GLP-1 patients sensitive to side effects, and patients managing PCOS, insulin resistance, or hormone transitions. Dr. Mortazavi confirms candidacy at consultation.
How much does the program cost?
$750 flat for the 90-day program. This includes the physician consultation, custom Tirzepatide dosing protocol, and monitoring check-ins over the 90 days. Cherry Financing and CareCredit are accepted.
Where is Plump Medical Spa?
4667 MacArthur Blvd, Suite 310, Newport Beach, CA 92660. Tuesday through Saturday, 10am to 6pm, by appointment only. Serving Newport Beach, Corona del Mar, Irvine, Costa Mesa, Laguna Beach, and all of Orange County. Call (949) 568-7544.
Book a consultation with Dr. Mortazavi to assess whether the 90-day GLP-1 microdosing program is right for your goals.
4667 MacArthur Blvd, Suite 310 · Newport Beach, CA 92660
(949) 568-7544 · Tuesday – Saturday, 10am – 6pm